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I know there is a nice review on the-digital-picture comparing the R6 to R5 noise at high-ISO and found them to be similar once the R5 images have been down-sized to that of the R6.  Is this your real-world experince. not that many have both R5 and R6 to compare.  In the end, do you have any issues with high-ISO noise with R5?

Generally speaking noise is not much of an issue with the new software for post processing regardless of the camera. (DXO PhotoLab Elite IV, Topaz DeNoise AI and many others.)